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View publications by year:
2003
The small-molecule approach to biology: Chemical genetics
and diversity-oriented organic synthesis make possible the systematic
exploration of biology" Stuart L. Schreiber, Chem. & Eng.
News, 2003, 81, 51-61.
From knowing to controlling: a path from genomics to
drugs using small molecule probes" Robert L. Strausberg and
Stuart L. Schreiber, Science, 2003, 300, 294-295.
Domain-selective small-molecule inhibitor of histone
deacetylase 6 (HDAC6)-mediated tubulin deacetylation" S.J.
Haggarty, K.M. Koeller, J.C. Wong, C.M. Grozinger, S.L. Schreiber,
Proc. Natl. Acad. Soc., 2003, 100, 4389-4394.
Structural biasing elements for in-cell histone deacetylase
paralog selectivity" Jason C. Wong, Roger Hong, Stuart L.
Schreiber, J. Am. Chem. Soc., 2003, 125, 5586-5587.
Mulitdimensional chemical genetic analysis of a combinatorial
library of deacetylase inhibitors using cell-based assays" Stephen
J. Haggarty, Kathryn M. Koeller, Jason C. Wong, Rebeccca A. Butcher,
Stuart L. Schreiber, Chem. Biol., 2003, 10, 383-396.
Chemical genetic modifier screens: Small molecule trichostatin
suppressors as probes of acetylation in transcription, cell cycle
progression, and stability of the cytoskeleton" Kathryn M.
Koeller, Stephen J. Haggarty, Brian D. Perkins, Igor Leykin, Jason
C. Wong, Ming-Chih J. Kao, Stuart L. Schreiber, Chem. & Biol.,
2003, 10, 397-410.
Expanding the Functinal Group Compatibility of Small-Molecule
Microarrays: Discovery of Novel Calmodulin Ligands" David
Barnes-Seeman, Seung Bum Park, Angela N. Koehler, and Stuart L.
Schreiber, Angewandte Chemie, 2003, 42, 2376-2379.
Development and validation of a T7 based linear amplicifation
for genomic DNA" Chih Long Liu, Stuart L. Schreiber, Bradley
E. Bernstein, BMC Genomics, 2003, 4, 19-29.
3Discovery of an inhibitor of a transcription factor
using small molecule microarrays and diversity-oriented synthesis" Angela
N. Koehler, Alykhan F. Shamji, Stuart L. Schreiber, J. Am. Chem.
Soc., 2003, 125, 8420-8421.
Catalytic Asymmetric [3+2] Cycloaddition of Azomethine
Ylides. Development of a Versatile Stepwise, Three-Component Reaction
for Diversity-Oriented Synthesis" Chuo Chen, Xiaodong Li,
Stuart L. Schreiber, J. Am. Chem. Soc., 2003, 125, 10174-10175.
A small molecule suppressor of FK506 that targets the
mitochondria and modulates ionic balance in Saccharomyces cerevisiae" Rebecca
Butcher, Stuart L. Schreiber, Chem. & Biol., 2003, 10, 521-531.
Chemical Genomic Profiling of Biological Networks Using
Graph Theory and Combinations of Small Molecule Perturbations" Stephen
J. Haggarty, Paul A. Clemons, Stuart L. Schreiber, J. Am. Chem.
Soc., 2003, 125, 10543-10545.
SIR1, an Upstream Component in Auxin Signaling Identified
by Chemical Genetics" Yunde Zhao, Xinhua Dai, Helen E. Blackwell,
Stuart L. Schreiber, Joanne Chory, Science, 2003, 301, 1107-1110.
Integration of Growth Factor and Nutrient Signaling:
Implications for Cancer Biology" Alykhan F. Shamji, Paul Nghiem,
and Stuart L. Schreiber, Molecular Cell, 2003, 12, 271-280.
Generating diverse skeletons of small molecules combinatoriallyî Martin
D. Burke, Eric M. Berger, Stuart L. Schreiber, Science, 2003, 302,
613-616.
Stereochemical control of skeletal diversityî Jason
K. Sello, Peter R. Andreana, Daesung Lee, Stuart L. Schreiber,
Org. Lett, 2003, 5, 4125-4127.
Methylation of Histone H3 K4 Mediates Association of
the Isw1p ATPase with Chromatin" Helena Santos-Rosa, Robert
Schneider, Bradley E. Bernstein, Nickoletta Karabesou, Antonin
Morillon, Christoph Weisse, Stuart L. Schreiber, Jane Mellor, Tony
Kouzarides, Molecular Cell, 2003, 12, 1325-1332.
Small Molecule Modulation of the Human Chromatid Decatenation
Checkpoint" Stephen J. Haggarty, Kathryn M. Koeller, Tweeny
R. Kau, Pamela A. Silver, Michel Roberge, Stuart L. Schrieber,
Chem. Biol., 2003, 10, 1267-1279.
2004
A planning strategy for diversity-oriented synthesis" Martin
D. Burke, Stuart L. Schreiber, Angewandte Chemie, 2004, 43, 46-58.
Macrolactones in Diversity-Oriented Synthesis: Preparation
of a Pilot Library and Exploration of Factors Controlling Macrocyclization" Darby
R. Schmidt, Ohyum Kwon, and Stuart L. Schreiber, J Comb Chem, 2004,
6, 286-292.
Synthetic Strategy toward Skeletal Diversity via Solid-Supported,
Otherwise Unstable Reactive Intermediates" Steven J. Taylor,
Alexander M. Taylor, Stuart L. Schreiber, Angewandte Chemie, 2004,
43, 1681-1685.
Chemical suppression of a genetic mutation in a zebrafish
model of aortic coarctation" Randall T. Peterson, Stanley
Y. Shaw, Travis A. Peterson, David J. Milan, Tao P. Zhong, Stuart
L. Schreiber, Calurn A. MacRae, Mark C. Fishman, Nature Biotech,
2004.
The use of chromatin immunoprecipitation assays in
genome-wide analyses of histone modificationsî Bradley E.
Bernstein, Emily L. Humphrey, Chih Long Liu and Stuart L. Schreiber.
In Allis C.D., Wu C., eds. Methods in Enzymology: Chromatin and
Chromatin Remodeling Enzymes 2004, 376, 350-361.
Paul Nghiem, Young-son Kim, Stuart L. Schreiber, "Protein
kinases as targets in cancer therapy: Validated and emerging approaches" Chapter
13, Pages 293-315 in Oncogenomics: Molecular Approaches to Cancer,
Ed., Charlie Brenner and David Duggan, John Wiley & Sons, 2004.
Rpd3p relocation mediates the transcriptional response
to rapamycin in yeastî Emily L. Humphrey, Alykhan F. Shamji,
Bradley E. Bernstein, Stuart L. Schreiber, Chem. & Biol., 2004,
11, 295-299.
Questions and Answers: Stuart L. Schreiberî,
Curr. Biol., 2004, 14, R292-R293.
Identification of Ald6 as the target of a class of
small molecule suppressors of FK506 and their use in network dissectionî Rebecca
A. Butcher and Stuart L. Schreiber, Proc. Natl. Acad. Sci., U.S.A.,
2004, 101, 7868-7873.
Global determinants of nucleosome occupancy in yeastî Bradley
E. Bernstein, Chih Long Liu, Emily L. Humphrey, Stuart L. Schreiber,
Genome Biology, 2004, 5:R62.
Modular synthesis and preliminary biological evaluation
of stereochemically and skeletally diverse 1,3-dioxanes" Jason
C. Wong, Scott M. Sternson, Joseph B. Louca, Roger Hong, Stuart
L. Schreiber, Chem. & Biol., 2004, 11, 1279-1291.
Mapping chemical space using molecular descriptors
and chemical genetics: Deacetylase inhibitors", Stephen J.
Haggarty, Jason C. Wong, Paul A. Clemons, Stuart L. Schreiber,
Comb. Chem. High Throughput Screen., 2004, 7, 669-676.
A synthesis strategy yielding skeletally diverse small
molecules combinatorially" Martin D. Burke, Eric M. Berger,
Stuart L. Schreiber, J. Am. Chem. Soc., 2004, 126, 14095-14104.
Syntheses of stereochemicaly diverse nine-membered
ring-containing biaryls" Shyam Krishnan and Stuart L. Schreiber,
Org. Lett., 2004, 6, 4021-4024.
Stereochemical control of the Passerini reaction" Peter
R. Andreana, Chang C. Liu, Stuart L. Schreiber, Org. Lett., 2004,
6, 4231-4233.
Finding new genetic modifiers of the TOR signaling
pathway through chemical genetics and proteome chips" Jing
Huang, Heng Zhu, Stephen J. Haggarty, David R. Spring, Heejun Hwang,
Fulai Jin, Michael Snyder, Stuart L. Schreiber, Proc. Natl. Acad.
Sci., U.S.A., 2004, 101, 16594-16599.
Relationship of stereochemical and skeletal diversity
of small molecules to cellular measurement spaceî Young-kwon
Kim, Midori A. Arai, Takayoshi Arai, Julia O. Lamenzo, Elton F.
Dean, III, Nick Patterson, Paul A. Clemons, Stuart L. Schreiber,
J. Am. Chem. Soc.,2004, 126, 14740-14745.
A Library of Spirooxindoles Based on a Stereoselective
Three-Component Coupling Reactionî Lo, M.M.-C.; Neumann,
C.S.; Nagayama, S.; Perlstein, E.O.; Schreiber, S.L. J. Am. Chem.
Soc.,2004, 126, 16077-16086.
2005
Skeletal diversity via a folding pathway: Synthesis
of Indole alkaloid-like skeletons" Hiroki Oguri and Stuart
L. Schreiber, Org. Lett., 2005, 7, 47-50.
Genomic maps and comparative analysis of histone
modifications in human and mouseî Bradley E. Bernstein, Michael
Kamal, Kerstin Lindblad-Toh, Stefan Bekiranov, Dione Kampa, Dana
J. Huebert, Scott McMahon, Edward J. Kulbokas III, Thomas R. Gingeras,
Stuart L. Schreiber, Eric S. Lander, Cell, 2005, 120, 169-181.
Using genome-wide transcriptional profiling to elucidate
small-molecule mechanism" Rebecca A. Butcher and Stuart L.
Schreiber, Curr. Op. Chem. Biol., 2005, 9, 25-30.
Convergent Diversity-Oriented Synthesis of Small-Molecule
Hybrids" Chuo Chen, Xiaodong Li, Christopher Neumann, Michael
M.-C. Lo, and Stuart L. Schreiber, Angew. Chem. 2005, 117, 2-4.
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